Previous intravenous oxygen insufflation treatments significantly reduced IL-1β levels in autologous conditioned serum from mean 67.85 pg/ml (before the first treatment) down to mean 4.08 pg/ml (before the 9th treatment). IL-1β and IL-1-RA levels were quantified from serum and from autologous conditioned serum (ACS) prepared from the drawn venous blood. Venous blood from 15 patients which underwent intravenous oxygen insufflation (IOI) for routinely preventive purposes was taken before the first, the 6th, and the 9th session of intravenous oxygen insufflation. The aim of the study was to analyze whether a pretreatment of patients with the oxygen insuffliation according to Regelsberger (IOI) might lead to an increased ratio of IL-RA to IL-1ß in autologous serum prepared after the respective therapy. In this regard, autologous conditioned serum with an IL-1Ra/IL-1 ratio of at least > 10 might fulfill optimal therapeutic effects.
Thus, if present in high enough concentrations, IL-1receptor antagonist (IL-1Ra) has the potential to inhibit Interleukin-1. Interleukin-1 (IL-1) is still regarded as the main offender that promotes the pro-inflammatory cascade in muscle injuries, tendopathies and especially in osteoarthritis.
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